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KMID : 0605720170230010053
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Journal of the Korean Society of Biological Therapies in Psychiatry
2017 Volume.23 No. 1 p.53 ~ p.61
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Characteristics of Depressive Symptoms in Patients with Amnestic Mild Cognitive Impairment
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Lee Ji-Min
Won Seung-Hee
Lee Seung-Jae
Chang Sung-Man
Kim Byung-Soo
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Abstract
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Objectives：Patients with mild cognitive impairment(MCI) are known to be commonly accompanied by depression. The aim of this study was to investigate the characteristics of depressive symptoms in patient with amnestic MCI(aMCI).
Methods：Three hundred and thirty two individuals were included in this study. They completed a comprehensive assessment, including the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet(CERAD-K), and a past psychiatric/medical history interview. Depressive symptoms were assessed using the revised Korean version of the Geriatric Depression Scale(GDS-KR). All patients were divided into three groups, aMCI group, non-amnestic mild cognitive impairment(naMCI) group, and cognitively normal group. We defined factor based score as total score of items belonging to each factor of GDS-KR. We compared depressive symptoms among three groups based on factor based score.
Results：The GDS-KR was meaningfully factored into five clearly separated factors(sad mood and agitation, positive mood, lack of energy, cognitive inefficiency, social withdrawal). In the factor of ‘lack of energy’, there was a significant difference among the three groups(p=0.048). In post-hoc analysis, the ‘lack of energy’ factor based score of aMCI was higher than that of the cognitively normal group(p=0.044).
Conclusion：These findings suggest that the pathophysiology of depression in aMCI may differ from that of depression in cognitively normal group. It is important to focus on lack of energy in treating depressive symptoms in aMCI.
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KEYWORD
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Mild cognitive impairmen, Aged, Depression, Apathy
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